1. There are matters going on in heaven with God that believer’s know nothing about; yet, they affect their lives.
2. Even the best effort at explaining the issues of life can be useless.
3. God’s people do suffer.  Bad things happen all the time to good people, so one cannot judge a person’s spirituality by his painful circumstances or successes.
4. Even though God seems far away, perseverance in faith is a most noble virtue since God is good and one can safely leave his life in his hands.
5. The believer in the midst of suffering should not abandon God, but draw near to him, so out of the fellowship can come the comfort – without the explanation.
6. Suffering may be intense, but it will ultimately end for the righteous and God will bless abundantly.

Copied from the introduction to Job in the MacArthur Study Bible.