One of my heroes of the faith, Jonathan Edwards, died suddenly and unexpectedly after taking a smallpox vaccination in 1758.  Shortly before his death, he wrote to his daughter Lucy:

“Dear Lucy, it seems to me to be the will of God that I must shortly leave you; therefore give my kindest love to my dear wife, and tell her, that the uncommon union, which has so long subsisted between us, has been of such a nature as I trust is spiritual and therefore will continue forever: and I hope she will be supported under so great a trial, and submit cheerfully to the will of God. And as to my children, you are now to be left fatherless, which I hope will be an inducement to you all to seek a Father who will never fail you.”

His wife, Sarah, was herself quite ill when she received the news by letter. On April 3, she wrote to her daughter Esther:

“What shall I say: A holy and good God has covered us with a dark cloud. O that we may kiss the rod, and lay our hands on our mouths! The Lord has done it. He has made me adore his goodness that we had him so long. But my God lives; and he has my heart. O what a legacy my husband, and your father, has left to us! We are all given to God: and there I am and love to be. Your ever affectionate mother, Sarah Edwards.”

Copied from “Jonathan Edwards: A Life” by George Marsden